Drug Uses

Zyrtec is an antihistamine. Antihistamines prevent sneezing, runny nose, itching and watering of the eyes, and other allergic symptoms. Zyrtec is used to treat allergies, hives (urticaria), and other allergic inflammatory conditions.

How Taken

Zyrtec comes as a tablet to take it orally. It usually is taken once a day. It may be taken regularly or when allergy symptoms flare up. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Zyrtec exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Warnings/Precautions

Before taking this medication, tell your doctor if you have kidney or liver disease. You may need a lower dose or special monitoring during your therapy with Zyrtec. Zyrtec is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take Zyrtec without first talking to your doctor if you are pregnant. Zyrtec passes into breast milk and may affect a nursing baby. Do not take Zyrtec without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from Zyrtec. You may require a lower dose of this medication.

Missed Dose

If you forget to take a dose, do not take an extra tablet to catch up for the dose you forgot. Wait and take your next tablet at the regular time. Do not take more tablets than your doctor prescribed.

Possible Side Effects

Stop taking Zyrtec and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives). Other, less serious side effects may be more likely to occur. Continue to take Zyrtec and talk to your doctor if you experience sleepiness, fatigue, or dizziness; headache; or dry mouth. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store at 20-25°C (68-77°F); excursions permitted to 15-30°C (59-86°F).

Overdose

Seek emergency medical attention. Symptoms of a Zyrtec overdose are not well known, but extreme sleepiness, confusion, and weakness may be expected.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Zyrtec may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Zyrtec.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Using Pitrakinra to inhibit interleukins-4 and -13 in the lungs may significantly reduce asthma symptoms, according to an article in the medical journal The Lancet, this week's issue.
The authors explain that doctors and scientists have believed for over twenty years that cytokines, such as interleukin-4 or interleukin-13 play a vital role in the onset and development of clinical asthma. However, there has been no scientific evidence that this might be so.
Dr Malinda Longphre, Aerovance Inc, Berkeley, California, USA and team carried out two separate Phase II clinical trials, where patients received Pitrakinra. In the first study 12 volunteers received 25mg of Pitrakinra by subcutaneous injection once per day. The patients in the second study were given either 60mg of Pitrakinra twice a day by nebulization, and another 16 received a placebo. In both trials the volunteers inhaled allergens before and four weeks after treatment - the allergens are designed to induce an asthma attack, the patient during an asthma attack of this type finds it harder to expel air.
The primary endpoint for the first trial was a maximum percentage drop in forced expiratory volume (FEV1)** in one second over 4-10 hours after receiving the allergen. In the second study the primary endpoint was average percentage fall in FEV1 over 4-10 hours after being given the allergen. If smaller falls in FEV1 during the asthma attack for the Pitrakinra group compared to the placebo group were detected, this would indicate that the allergic response had been reduced by Pitrakinra.
In the first study, say the researchers, the maximum percentage fall in FEV1 was 17.1% in the Pitrakinra and 23.1% in the placebo groups - a comparable difference of 26%. In the second study the average percentage drop in FEV1 was 4.4% in the Pitrakinra versus 15.9% in the placebo group - in other words, it was over three and a half times less in the Pitrakinra group.
"The effects of pitrakinra on late phase asthmatic response are promising when compared with similar studies with other successful anti-inflammatory asthma therapies...whether the effect is due to inhibition of interleukin-13 alone, or both interleukin-13 an interleukin-4, is not yet known. Future studies of this drug, as well as molecules that specifically inhibit interleukin-13, in asthmatic individuals of all levels of severity over longer periods of time are clearly warranted," the writers conclude.

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