Drug Uses

Zithromax is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, skin infections, ear infections, and sexually transmitted diseases.

How Taken

Zithromax comes as a capsule, tablet, and liquid to take it orally. It is usually taken once a day for 2-5 days. Take Zithromax exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid well before each use to mix the medication evenly. The capsules and tablets should be taken with a full glass of water. Continue to take Zithromax even if you feel well. Do not stop taking Zithromax without talking to your doctor. Take Zithromax liquid at least 1 hour before or 2 hours after meals. The capsule and tablet may be taken with or without food. If it upsets your stomach, take it with food.

Warnings/Precautions

Before taking Zithromax, tell your doctor if you have liver disease. You may not be able to take Zithromax, or you may require a lower dose or special monitoring during treatment. Zithromax is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Zithromax passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Zithromax and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue). Other, less serious side effects may be more likely to occur. Continue to take Zithromax and talk to your doctor if you experience nausea, vomiting, diarrhea, or abdominal pain; unusual dizziness, fatigue, or headache; vaginal yeast infection; a rash; or increased sensitivity to sunlight. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Zithromax tablets should be stored between 15° to 30° C (59° to 86°F). Store constituted suspension between 5° to 30°C (41° to 86°F) and discard when full dosing is completed or within 10 days. Shake well before each use. Oversized bottle provides shake space. Keep tightly closed.

Overdose

Seek emergency medical attention. Symptoms of Zithromax overdose include nausea, vomiting, diarrhea, and abdominal discomfort.

More Information

Avoid prolonged exposure to sunlight. Zithromax may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Japanese researchers have reported the genome sequence of Streptomyces avermitilis, a free-living bacterium that grows in the soil. The bacterium is commercially important for human and veterinary medicine because it is one of the main producers of antibiotics. The sequencing revealed many genes involved in producing natural antibiotics that reside in clusters near both ends of the linear-shaped chromosome. These gene clusters interest researchers because understanding the antibiotic-producing mechanism could help generate novel drugs and slow down antibiotic resistance.
For bacterial standards, S. avermitilis has an unusually large genome of at least 8.7 million base pairs that consists of one linear chromosome. The team of researchers headed by Satoshi Omura, of the Kitasato Institute, in Tokyo, Japan, analyzed 99 percent of the genome using the whole-genome shotgun sequencing method. Altogether, they found at least 7,600 genes. Researchers have attributed the large genome size to extremely variable environmental factors the bacterium has to face as a free-living organism in the soil.
"The most interesting property of Streptomyces is its ability to produce secondary metabolites including antibiotics and bioactive compounds valued in human and veterinary medicine, agriculture, and unique biochemical tools," Omura—a specialist in the chemistry of natural products—and colleagues write in Proceedings of the National Academy of Sciences. Secondary metabolites are compounds with antibacterial, antifungal, and antiviral properties and encompass a large variety of antibiotics. Researchers believe that these metabolites are produced by the bacterium at the end of its vegetative growth.
The scientists identified 25 kinds of gene clusters related to secondary metabolites. Even though these clusters are spread throughout the chromosome, the researchers were surprised to find about half of them located near both ends of the chromosome. "Some of the secondary metabolite clusters might have been horizontally transferred from donor microorganisms in the past," the researchers suggest.
Out of the 25 gene clusters, eight were found to produce compounds called avermectins. Avermectins are among the most important drugs for treating parasitic infections of livestock and humans, according to the researchers. The bacterial strain used in the study is S. avermitilis ATCC31267.
Why Streptomyces produce so many kinds of antibiotics and bioactive compounds is not yet fully understood. "One of the answers," Omura and his team suggest, "is that Streptomyces strains have many gene clusters, which encode enzymes for many secondary pathways."

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