Drug Uses

Valtrex is indicated for the treatment of herpes zoster (shingles), for the treatment or suppression of genital herpes in immunocompetent individuals and for the suppression of recurrent genital herpes in HIV-infected individuals and is also indicated for the treatment of cold sores (herpes labialis).

How Taken

Valtrex comes as a tablet to take it orally. It is usually taken every 8 hours (three times a day) for 7 days to treat shingles. To treat genital herpes it is usually taken twice a day for 5 days. For cold sores, Valtrex is usually taken for one day only. Do not take more or less of it or take it more often than prescribed by your doctor. Use this medication as soon as possible after symptoms appear. Continue to take Valtrex even if you feel well. Do not stop taking Valtrex without talking to your doctor.

Warnings/Precautions

Do not take Valtrex without first talking to your doctor if you are allergic to acyclovir (Zovirax). Before taking this medication, tell your doctor if you have kidney disease or immune system problems. You may need a dosage adjustment or special monitoring during treatment with Valtrex. Valtrex is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Valtrex passes into breast milk and how it may affect a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

If you miss a dose of Valtrex, take it as soon as you remember and then take your next dose at its regular time. However, if it is almost time for your next dose, do not take the missed dose. Wait and take the next dose at the regular time.

Possible Side Effects

Kidney failure and nervous system problems are not common, but can be serious in some patients taking Valtrex. Nervous system problems include aggressive behavior, unsteady movement, shaky movements, confusion, speech problems, hallucinations (seeing or hearing things that are really not there), seizures, and coma. Kidney failure and nervous system problems have happened in patients who already have kidney disease and in elderly patients whose kidneys do not work well due to age. Always tell your healthcare provider if you have kidney problems before taking Valtrex. Call your doctor right away if you get a nervous system problem while you are taking Valtrex. Common side effects of Valtrex include headache, nausea, stomach pain, vomiting, and dizziness. Side effects in HIV-infected adults include headache, tiredness, and rash. These side effects are usually mild and usually do not cause patients to stop taking Valtrex. Other less common side effects include painful periods in women, joint pain, depression, low blood cell counts, and changes in tests that measure how well the liver and kidneys work.

Storage

Store at 15° to 25°C (59° to 77°F).Keep Valtrex a tightly closed container. Do not keep medicine that is out of date or that you no longer need. Keep Valtrex and all medicines out of the reach of children.

Overdose

Seek emergency medical treatment if an overdose is suspected. The symptoms of an overdose of Valtrex are not well known, but an overdose of acyclovir (Zovirax), which is a similar drug, may cause seizures, hallucinations, and kidney damage (decreased urine production).

More Information

Herpes infections are contagious and you can infect other people, even during treatment. Avoid letting infected areas come into contact with other people. Wash your hands frequently to prevent transmission. Valtrex will not prevent the spread of genital herpes. Avoidance of sexual intercourse and use of latex condoms may prevent spreading the virus to others.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Genital herpes is a highly contagious viral condition caused by the herpes simplex virus (HSV). It principally infects the skin and mucous membranes of the genitals and rectum, but can also appear in areas such as the mouth. It is transmitted primarily through physical and sexual contact. During birth, the presence of herpes simplex virus on the genitalia or in the birth canal is a threat to the infant. Infection in the newborn infant can lead to herpetic meningitis, herpetic viremia (herpes virus particles present in the blood) and chronic skin infection
The symptoms of herpes simplex virus usually occur a week after infection, but sometimes take longer to appear. Initially, the skin becomes reddened and multiple small blisters filled with a clear, straw-coloured fluid appear. Prior to the presence of blisters, the infected individual may also experience increased skin sensitivity, tingling, burning or pain at the site where blisters will appear. Later, the blisters burst leaving shallow, painful ulcers which eventually scab and heal over a period of 7 to 14 days.
The outbreak may be accompanied by other symptoms such as:
# swelling and tenderness of the lymph nodes in the groin area.
# in women, vaginal discharge and painful urination.
# in men, a possibility of painful urination if the lesion is near the opening of the urethra.
# fever.
In most cases, a description of the condition and the appearance of the blisters will be enough to make a diagnosis. The GP may also advise referral to a specialist genitourinary medicine (GUM) clinic for confirmation of the diagnosis.
There is no cure for the herpes simplex virus; once infected, patients will remain a carrier for the rest of their lives. Some remedies, however, can reduce the duration of the eruption. In addition, by being more aware of the initial symptoms of recurrence (skin sensitivity and tingling), timely treatment with medication such as aciclovir (Zovirax tablets/suspension) will often abort the outbreak of blisters.
The best way to prevent recurrence is to avoid direct contact with an open lesion. People with herpes simplex virus should avoid sexual contact when active lesions are present.
Although the symptoms of genital herpes may not be present, it is important for those infected to inform their partner that they have the disease. This will encourage both parties to use barrier protection (condoms) to prevent the spread of the illness. Using condoms and not sharing towels are good ways of reducing the chance of infection in the first place.
For more information, read the factsheet on Herpes genitals.

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