Drug Uses

Fioricet is a barbiturate sedative mixed with a non-aspirin pain medication and caffeine. This non-narcotic pain medication and relaxant is often prescribed for tension headaches caused by contractions of the muscles in the neck and shoulder area, and migraine.

How Taken

Fioricet comes as a capsule and tablet to take by mouth. One or 2 tablets every 4 hours as needed. Total daily dosage should not exceed 6 tablets. Extended and repeated use of this product is not recommended because of the potential for physical dependence.

Warnings/Precautions

Fioricet may cause you to become drowsy or less alert; therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended until you know your response to this drug. If you are being treated for severe depression or have a history of severe depression or drug abuse, consult with your doctor before taking Fioricet. Use this drug with caution if you are elderly or in a weakened condition, if you have liver or kidney problems, or if you have severe abdominal trouble. If you are pregnant or plan to become pregnant, inform your doctor immediately. Fioricet can affect a developing baby. It also appears in breast milk. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding your baby until your treatment is finished.

Missed Dose

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Possible Side Effects

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Fioricet. More common side effects may include: Abdominal pain, dizziness, drowsiness, intoxicated feeling, light-headedness, nausea, sedation, shortness of breath, vomiting. Less common or rare side effects may include: Agitation, allergic reactions, constipation, depression, difficulty swallowing, dry mouth, earache, exaggerated feeling of well-being, excessive sweating, excessive urination, excitement, fainting, fatigue, fever, flatulence, headache, heartburn, heavy eyelids, high energy, hot spells, itching, leg pain, mental confusion, muscle fatigue, numbness, rapid heartbeat, ringing in the ears, seizure, shaky feeling, skin redness and/or peeling, sluggishness, stuffy nose, tingling.

Storage

Store below 86° F (30° C); dispense in a tight container and out of reach of children.

Overdose

An overdose of Fioricet, or combining this medication with alcohol or other central nervous system depressant, may lead to unconsciousness or perhaps death. Fioricet overdose is indicated by severe drowsiness, confusion, extreme weakness, hallucination, shortness of breath, too slow or troubled breathing, slurred speech, lack of coordination, vomiting with blood, unusually slow heartbeat.

More Information

Do not take Fioricet if you have taken a monoamine oxidase inhibitor (MAOI) in the last 14 days. Dangerous side effects could result. Fioricet may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), other pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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The nutritional supplement glucosamine boosts the pain relieving power of ibuprofen, according to a new study by Temple University researchers in the Journal of Pharmacology and Experimental Therapeutics (JPET). This new drug combination could one day allow patients to take a lower dose and get the same pain relief with fewer unwanted side effects. Ronald Tallarida, Ph.D., and Alan Cowan, Ph.D., of Temple's School of Medicine, and Robert Raffa, Ph.D., of Temple's School of Pharmacy, conducted the study "Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice," which was published in the November 2003 issue of JPET. Ibuprofen is a non-steroidal anti-inflammatory drug, or NSAID. NSAIDs, which also include aspirin, are quite effective in relieving pain. They are so effective, in fact, that pain sufferers sometimes take higher and higher doses in hope of more pain relief. High doses of NSAIDs, especially when taken over long periods of time, can cause gastrointestinal upset, such as heartburn, or even bleeding. "Combining pain relievers into one pill can increase patient compliance, simplify prescribing, and improve efficacy without increasing side effects, or conversely, decrease side effects without losing efficacy," said Raffa. In addition to these benefits, drug combinations can also sometimes yield a totally unexpected effect, such as the magnification of a drug's powers. "When this happens, a phenomenon known as drug synergism, it's like finding buried treasure," added Tallarida. Glucosamine, a naturally occurring substance in the body, which is also available in synthetic form over the counter, is used to treat osteoarthritis, a painful, degenerative joint disorder. While it has been shown to prevent and repair bone and cartilage damage, researchers have yet to demonstrate that glucosamine actually blocks pain. "We embarked on this study with several questions: Can glucosamine actually block pain? And, can glucosamine improve the pain-relieving powers of other drugs when the two are combined?" said Tallarida. First, the researchers confirmed that glucosamine, alone, does not block pain. It's believed that any pain-relieving properties of glucosamine are a side effect of its ability to repair bone damage. Next, they combined glucosamine with a variety of NSAIDs at a variety of dosages. With several NSAIDs, including naproxen, the addition of glucosamine caused an additive effect, meaning the sum of each drug's properties. When combined with aspirin or acetaminophen, the result was subadditive, or less than the sum of each drug's properties. But when combined with ibuprofen, the researchers found pain relief was enhanced and therefore synergistic. "The next step will be to study this drug combination in clinical trials to see whether it can enhance pain relief or offer pain relief using a lower dose of ibuprofen and therefore a lower risk of side effects," said Cowan. The researchers are also investigating other possible drug combinations for the potential relief of pain. Raffa and Tallarida played a role in the development of Ultracet, a combination of tramadol and acetominophen used in the treatment of pain. And Cowan contributed to the development of buprenorphine which, when combined with naloxone, is used in the treatment of opiate addiction.

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