Drug Uses

Use Estrandiol to reduce moderate to severe menopausal symptoms, to treat vulval and vaginal atrophy, treat certain cancers in special situations and prevent the thinning of bones.

How Taken

Talk to your local physician or pharmacist. You and your doctor should reevaluate whether or not you still need estrogens at least every six months.

Warnings/Precautions

If you think you may be pregnant, do not use any form of estrogen-containing drug. Using Estrandiol while you are pregnant may cause your unborn child to have birth defects. Estrandiol does not prevent miscarriage.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Possible Side Effects

The following side effects have been reported with use of this medicine: nausea and vomiting; breast tenderness or enlargement; enlargement of benign tumors; retention of excess fluid (this may make some conditions worsen, such as asthma, epilepsy, migraine, heart disease, or kidney disease); a spotty darken of the skin, particularly on the face.

Storage

Store at controlled room temperature 15°C to 30°C (59°F to 86°F). Keep this and all drugs out of the reach of children.

Overdose

In case of overdose, call your doctor, hospital or poison control center immediately.

More Information

You are cautioned to discuss very carefully with your doctor or health care provider all the possible risks and benefits of long-term estrogen and progestin treatment as they affect you personally.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Estrogen injections might help keep women's minds sharp as they age, a new study of female monkeys suggests.
For the study, published in this week's online issue of the Proceedings of the National Academy of Sciences, researchers at Mount Sinai School of Medicine, in New York City, removed the ovaries of four distinct groups of female rhesus monkeys. One group included old monkeys that received estrogen; a second group included old monkeys that did not receive estrogen; and there were two other groups of young monkeys that either received or did not receive estrogen.
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Removing the monkeys' ovaries induced menopause. The older monkeys had their ovaries removed around the time of perimenopause -- before the onset of full menopause.
Estrogen treatment involved pure estradiol injections every 21 days. The researchers periodically tested the monkeys on a series of cognitive tasks over the course of more than two years.
Older monkeys that were treated with estrogen performed almost as well as the younger monkeys on the mind-challenging tests, the researchers reported, while untreated older monkeys showed dramatic cognitive declines.
Surprisingly, the younger monkeys performed equally well whether or not they were treated with estrogen.
The study also found that the estrogen-treated monkeys showed brain changes associated with the prevention of cognitive decline. On the other hand, the older untreated monkeys showed no signs of these changes.
The findings suggest that the debate over whether hormone replacement therapy is beneficial may not be over, according to study co-author John H. Morrison, dean of basic sciences and the graduate school of biological sciences at Mount Sinai.
"There's been a great deal of confusion as to whether estrogen helps or harms postmenopausal women, and our findings tell us is that there is a very critical window of opportunity in which estrogen may be helpful," he said in a prepared statement.
He noted that this critical window could be around the time of perimenopause, when estrogen may be able to protect the brain from cognitive decline.
"Estrogen levels decline in old age, so the brain may need a certain amount of circulating estrogen to remain supple. Timing may be everything," Morrison said.

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