Drug Uses

Effexor XR is a potent inhibitor of the reuptake of serotonin and norepinephrine-two neurotransmitters thought to play important roles in the pathophysiology of depression. Correcting the imbalance of these two chemicals may help relieve symptoms of depression.

How Taken

Effexor XR comes as a capsule to take by mouth. It is usually taken once a day and should be taken with food. Each capsule should be swallowed whole with fluid and not divided, crushed, chewed, or placed in water, or it may be administered by carefully opening the capsule and sprinkling the entire contents on a spoonful of applesauce. This drug/food mixture should be swallowed immediately without chewing and followed with a glass of water to ensure complete swallowing of the pellets.

Warnings/Precautions

Before starting Effexor XR, tell your doctor about any medicines you're taking, including over-the-counter drugs and herbal supplements. If you take MAOIs you should not take Effexor XR. If you are taking antidepressants you should be watched closely for signs that your condition is getting worse or that you are becoming suicidal, especially when you first start therapy, or when your dose is increased or decreased. You should also be watched for becoming agitated, irritable, hostile, impulsive, or restless. Such symptoms should be reported to your doctor right away. Effexor XR may raise blood pressure in some patients, so blood pressure should be monitored regularly. When you suddenly stop using or quickly lower your daily dose of Effexor XR, discontinuation symptoms may occur. Talk to your doctor before discontinuing or reducing your dose of Effexor XR. Pregnant or nursing women shouldn't take any antidepressant without consulting their doctor. Until you see how Effexor XR affects you, be careful doing such activities as driving a car or operating machinery. Avoid drinking alcohol while taking Effexor XR.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next one as directed. Do not take a double dose of this medication.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Effexor XR and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); seizures; or an irregular heartbeat or severely high blood pressure (blurred vision, headache). Other, less serious side effects may be more likely to occur. Continue to take Effexor XR and talk to your doctor if you experience nausea, vomiting, upset stomach, abdominal pain, or loss of appetite or weight; dry mouth; drowsiness or dizziness; mild tremor, anxiety, or agitation; insomnia; abnormal dreams; sexual problems such as impotence, abnormal ejaculation, difficulty reaching orgasm, or decreased libido; sweating; yawning; or increase in blood cholesterol levels (detected by blood tests); Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store Effexor XR at room temperature (68F to 77F or 20C to 25C). Keep Effexor XR away from children.

Overdose

Seek emergency medical attention if an overdose is suspected. Symptoms of an Effexor XR overdose may include dizziness, drowsiness, numbness, nausea, irregular heartbeats, seizures, and unconsciousness.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Effexor XR may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness, dizziness, and confusion Do not stop taking Effexor XR without first talking to your doctor. Your doctor may need to gradually reduce the dose before stopping the medication completely. Stopping the medication suddenly may cause unpleasant side effects to occur.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Dr. Peter Schlegel of the Cornell Medical Center in New York, along with a colleague, recently treated two men for infertility and found when both patients stopped taking their prescription antidepressant medications -- selective serotonin reuptake inhibitors (SSRIs) -- their sperm counts dramatically increased. Schlegel then observed that when both men re-started their antidepressants, their fertility problems returned.
One patient was taking citalopram -- sold as Cipramil -- and the other was on sertraline, sold as Lustral. The second patient switched to venlafaxtine -- Effexor -- and again his sperm count dropped to near zero. Schlegel believes that because SSRI drugs affect both sperm count and the ability of sperm to move, the antidepressants may be preventing sperm from reaching the semen.
"The patients had normal sperm counts and motility before medication," Schlegel said. "On the medication they have deterioration of both. The same patients going on and off medication had the same pattern. It shows a strong association."
The U.S. Food and Drug Administration required most SSRI drugs to carry the agency's strongest "black box" warning in 2004 for their association with increased risk of suicide. Other common side effects of the drugs include impotence and delayed ejaculation.
Allan Pacey, senior lecturer in andrology at the University of Sheffield, said, "There does seem to be a major correlation. Maybe this is an unknown side effect of these drugs that is only just coming to light."
Schlegel's study linking low sperm count to SSRI drug use noted that an additional dozen patients reported similar effects from the antidepressants. Because of the small number of patients involved, the study's implications need verification, Schlegel said. A clinical trial involving 30 male patients taking sertraline has begun to bolster Schlegel's findings.
The researchers warned that men taking SSRIs to treat mental disorders, who are concerned about low sperm counts, should not alter their drug use without consulting a qualified medical professional.

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