Drug Uses

Clarinex is an antihistamine used to relieve the symptoms of hay fever (seasonal allergic rhinitis). Clarinex contains a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.

How Taken

Clarinex comes in tablets to take by mouth. It can be taken with or without food and is usually taken once daily. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Clarinex exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Warnings/Precautions

Before taking Clarinex, tell your doctor if you have ever had an allergic reaction to an antihistamine; kidney disease; or liver disease. You may not be able to take Clarinex, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Clarinex is in the FDA pregnancy category C. This means that it is not known whether Clarinex will be harmful to an unborn baby. Do not take Clarinex without first talking to your doctor if you are pregnant or could become pregnant during treatment. Clarinex passes into breast milk and may affect a nursing infant. Do not take Clarinex without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

If you miss a dose take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

Possible Side Effects

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Clarinex. More common side effects may include: dry mouth, fatigue, sleepiness, sore throat. Less common side effects may include: dizziness, dry throat, flu-like symptoms, muscle pain, nausea. Rare side effects may include: acute allergic reaction, hives, itching, rapid heartbeat, rash, shortness of breath, swelling.

Storage

Store at room temperature. Protect from heat. Keep this medication in the container it came in, tightly closed, and out of reach of children.

Overdose

Little is known about the effects of a Clarinex overdose. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately. Symptoms of Clarinex overdose may include: rapid heartbeat, sleepiness.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Although unlikely, Clarinex may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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It's known that exposure to ozone is associated with increased cardiovascular and pulmonary hospitalizations and deaths, but the actual mechanisms involved haven't been clarified. This study, by Duke University Medical Center pulmonary researchers, may provide some answers.
They found that mice exposed to unhealthy ozone levels showed amplified lung injury in response to bacterial toxins. The rodents also showed increased "programmed cell death" of the type of innate immune system cells that normally devour foreign invaders and keep the airways clear.
The innate immune system -- the most primitive part of the body's defenses -- reacts indiscriminately to any invader.
"Small amounts of inhaled foreign material can be relatively harmless, since they stimulate an appropriate innate immune response that protects the lungs," study lead author and pulmonologist Dr. John Hollingsworth, said in a prepared statement.
"However, it appears that ozone causes the innate immune system to overreact, killing key immune cells, and possibly making the lung more susceptible to subsequent invaders, such as bacteria," he said.
The study is published in the Oct. 1 issue of the Journal of Immunology.

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