Drug Uses

Carisoprodol is a muscle relaxant used to relieve the pain and stiffness of muscle spasms and discomfort due to strain and sprain.

How Taken

Carisoprodol is taken orally. The usual adult dosage of Carisoprodol is one 350 mg tablet, three times daily and at bedtime. Usage in patients under age 12 is not recommended. It is recommended that you take Carisoprodol with food, or with milk, to minimize the likelihood that you will suffer an upset stomach as a result of taking the medication.

Warnings/Precautions

Do not take Carisoprodol if you have acute intermittent porphyria. Before taking Carisoprodol, tell your doctor if you have kidney or liver disease. You may need a lower dose or special monitoring during your therapy. It is not known whether Carisoprodol will harm an unborn baby. Do not take Carisoprodol without first talking to your doctor if you are pregnant. It is also not known whether Carisoprodol passes into breast milk. Do not take Carisoprodol without first talking to your doctor if you are breast-feeding a baby. Carisoprodol is not approved for use in children younger than 12 years of age.

Missed Dose

If you miss a Carisoprodol dose, take it as soon as remembered if it is within an hour or so. If you do not remember until later, skip the missed dose and resume your usual dosing schedule. Do not 'double-up' the Carisoprodol dose to catch up.

Possible Side Effects

Carisoprodol may cause dizziness, vertigo, ataxia, tremor, agitation, irritability, headache, depressive reactions, syncope, and insomnia. Allergic or idiosyncratic reactions occasionally develop. They are usually seen within the period of the first to fourth dose in patients having had no previous contact with the drug. Skin rash, erythema multiforme, pruritus, eosinophilia, and fixed drug eruption with cross reaction to meprobamate have been reported with Carisoprodol. Severe reactions have been manifested by asthmatic episodes, fever, weakness, dizziness, angioneurotic edema, smarting eyes, hypotension, and anaphylactoid shock.

Storage

Store at controlled room temperature 15°-30°C (59°-86°F). Dispense in a tight container.

Overdose

Seek emergency medical attention. Symptoms of a Carisoprodol overdose include low blood pressure (weakness, fainting, confusion), decreased breathing, and unconsciousness.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Carisoprodol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Carisoprodol.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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RANCHO MIRAGE, CALIF. -- An antispasticity drug, tizanidine, appeared to be effective in treating analgesic rebound headache, chronic tension-type headache, and related pain disorders in several retrospective or open-label prospective trials.
Response to treatment with tizanidine (Zanaflex) for chronic daily headache did not seem to differ in patients based on whether or not they had musculoskeletal symptoms such as spasticity, Dr. Timothy, R. Smith said at a meeting sponsored by the Diamond Headache Clinic.
He conducted a retrospective review of 53 patients at his clinic treated for chronic daily headache that was thought to be caused by analgesic overuse.
The patients were given tizanidine (2 mg to start, titrated up as tolerated), together with a once-daily long-acting NSAID (naproxen) or COX-2 inhibitor (Celecoxib), while eliminating other analgesics.
After 12 weeks, 38 patients (71%) stopped having chronic daily headache and reverted to intermittent headaches, said Dr. Smith of Ryan Headache Center, Chesterfield, Mo.
A separate retrospective review of charts and headache diaries for 62 patients with chronic daily headache found no association between response to tizanidine and the presence of musculoskeletal symptoms, suggesting that the drug's effects on headache are due to factors other than muscle relaxation, he added.
The drug reduced the frequency of headache by at least half in 46 (74%) of patients, 34 (74%) of whom had muscle spasticity at baseline. Muscle spasticity was pre sent in 11 (69%) of nonresponders, a rate that was not significantly different from the responders group, Dr. Smith reported.
"The presence of musculoskeletal symptoms could not predict a clinical response to tizanidine," he said.
Elan Pharmaceuticals, the maker of tizanidine, funded the studies. Dr. Smith has served on the speaker's bureau for Elan Pharmaceuticals and for eight other drug companies.
A separate review of poster presentations on tizanidine at previous medical meetings found four small uncontrolled studies suggesting benefit from treating certain pain syndromes with the drug, Dr. Gary E. Ruoff reported in a separate poster presentation at the meeting.
His review also was funded by Elan Pharmaceuticals. Dr. Ruoff serves on the speaker's list for Elan and five other drug companies.
One open-label trial by Dr. Smith and his associates used 3.6 mg tizanidine daily in 70 patients with analgesic rebound headache who were transitioning to decreased NSAID use, Dr. Ruoff reported.
After 12 weeks, 46 patients (66%) discontinued their chronic NSAID use without worsening headaches. Three patients (4%) experienced treatment-limiting adverse effects, said Dr. Ruoff, who is in practice in Kalamazoo, Mich.
A second open-label trial of 220 patients with recalci- trant chronic tension-type headache who were titrated up to a mean dose of 26 mg tizanidine daily found a response after 10 weeks in 150 patients (68%), reducing headache frequency by a mean of 73%.
In this study, 13 patients (6%) experienced treatment-limited adverse effects.
A third open-label trial of 4-8 mg tizanidine daily in 26 patients with fibromyalgia found decreases on average in the number of tender points, improvements in global assessment scores, Fibromyalgia Impact Questionnaire scores, and visual analog scores after 8 weeks.
In a retrospective chart review, 20 patients who had traumatically induced myofascial pain were given 2-6 mg tizanidine three times daily. Improvements in pain symptoms--including headache--were noted in 14 of the patients (70%) after 4-6 weeks. The drug was well tolerated.
Tizanidine is an imidazoline derivative, an [[alpha].sub.2]-agonist that is structurally related to clonidine.
Many patients with chronic daily headache are thought to have a down regulation of norepinephrine receptors caused by excessive release of norepinephrine from the locus ceruleus.
Tizanidine has been shown to decrease norepinephrine release in the central nervous system. This effect may help restore the homeostatic balance of norepinephrine, thereby reducing patients' perception of pain, Dr. Ruoff speculated.

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