Drug Uses

Albenza is indicated for the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm. This medicine may also be used for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm.

How Taken

Albenza should be taken with food.

Warnings/Precautions

Albenza may cause fetal harm, therefore, you should begin treatment after a negative pregnancy test. During therapy, because of the possibility of harm to the liver or bone marrow, routine (every 2 weeks) monitoring of blood counts and liver function tests should take place. Talk to your doctor about possible harm to the fetus if you plan on becoming pregnant while on Albenza or within 1 month of completing treatment.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Possible Side Effects

The symptoms are usually mild and resolved without treatment.

Storage

Store between 20° and 25°C (68° and 77°F).

Overdose

In case of overdosage, symptomatic therapy and general supportive measures are recommended. Seek emergency medical attention.

More Information

If you suffer of hypersensitivity to the benzimidazole class of compounds or any components of Albenza, talk to your doctor before taking this medicine.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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COLUMBUS, Ohio – A drug once used to fight exotic tropical diseases and parasitic infections is now being teamed up with a popular chemotherapeutic agent to treat some of the most stubborn cases of advanced breast cancer.
A phase I trial will test the combination of suramin and paclitaxel in a small handful of patients at the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. The study builds upon several years of research in The Ohio State University Comprehensive Cancer Center (OSUCCC) that have resurrected suramin as a possible way to render chemotherapy more effective.
“This is certainly an innovative way to treat metastatic breast cancer,” says Dr. Charles Shapiro, director of breast medical oncology at The James and principal investigator of the study. “Based on earlier studies, we feel it may be a way for patients to benefit more fully from standard treatment.”
Historically, suramin has been used to treat patients with parasitic infections like African sleeping sickness and river blindness. It was initially tested as an antitumor drug several decades ago, but investigators found it was too toxic at the levels they believed might have been helpful, and it fell from favor.
Scientists in the OSUCCC, however, continued to be impressed with suramin’s anti-tumor activity, and through recent experiments, discovered it could block certain agents called fibroblast growth factors – proteins tumors secrete to help them build chemoresistance, or the ability to withstand the onslaught of chemotherapy.
Led by Dr. Jessie L.-S. Au, Distinguished University Professor, Dorothy M. Davis professor of cancer research at Ohio State and member of the OSUCCC’s Experimental Therapeutics program, a team of scientists began testing lower doses of suramin, and discovered that when suramin is combined with chemotherapy, less is more.
In early experiments with mice injected with human lung cancer cells, chemotherapy alone reduced the size of tumors by 80 percent, but when researchers added low doses of suramin, the tumors shrank in size even more, and were completely eliminated in 42 percent of the animals. Similar results were found in studies on mice implanted with human prostate cancer cells. In an early with trial with 12 patients with non-small cell lung cancer, suramin added to paclitaxel and carboplatin blocked the growth of the cancers in almost two-thirds of the patients for at least nine months, and in some of the patients, the tumors actually shrank.
“Breast cancer is much harder to treat once it spreads. In addition, it tends to grow more resistant to chemotherapy over time. Anything we can do to undermine that resistance could potentially be helpful to the patient,” says Shapiro.
According to the American Cancer Society, there will be over 190,000 new cases of breast cancer in the United States this year. Breast cancer is the second leading cause of cancer death among women.
The suramin trial is open to women with stage IIIb or IV breast cancer. Suramin and paclitaxel will be administered weekly. Researchers will study patients’ response to varying doses, and will monitor any side effects and disease response.
The Arthur G. James Cancer Hospital and Richard J. Solove Institute, located on the campus of The Ohio State University, is the only free-standing cancer hospital in the Midwest. It is a founding member of the National Comprehensive Cancer Network and consistently ranked by U.S. News and World Report as one of America’s best cancer hospitals.

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